Concept information
Preferred term
Apoptosomes
Type
-
Topical Descriptor
Broader concept
Entry terms
- Apoptosomal Protein Complex
- Apoptosome
- Complex, Apoptosomal Protein
- Protein Complex, Apoptosomal
Scope note
- Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
History note
- 2007
In other languages
-
Finnish
-
apoptosomi
-
Swedish
URI
http://www.yso.fi/onto/mesh/D053478
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