Concept information
Preferred term
Presenilins
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- Presenilin
Scope note
- Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
History note
- 2007
In other languages
-
Finnish
-
preseniliini
-
Swedish
URI
http://www.yso.fi/onto/mesh/D053763
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