Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Presenilins > Presenilin-2

Preferred term

Presenilin-2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Presenilin 2

Scope note

  • Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

History note

  • 2007

In other languages

URI

http://www.yso.fi/onto/mesh/D053766

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/5/06, last modified 6/25/10