Concept information
...
Proteins
Intercellular Signaling Peptides and Proteins
Cytokines
Transforming Growth Factor beta
Biological Factors
Intercellular Signaling Peptides and Proteins
Cytokines
Transforming Growth Factor beta
...
Peptides
Intercellular Signaling Peptides and Proteins
Cytokines
Transforming Growth Factor beta
...
Proteins
Intercellular Signaling Peptides and Proteins
TGF-beta Superfamily Proteins
Transforming Growth Factor beta
Preferred term
Transforming Growth Factor beta1
Type
-
Topical Descriptor
Broader concept
Entry terms
- TGF beta 1
- TGF-beta-1
- TGF-beta1
- Transforming Growth Factor-beta1
- Transforming Growth Factor beta I
Scope note
- A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
History note
- 2007(1992)
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D053773
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