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Concept information

Preferred term

Transforming Growth Factor beta1  

Type

  • Topical Descriptor

Entry terms

  • TGF beta 1
  • TGF-beta-1
  • TGF-beta1
  • Transforming Growth Factor-beta1
  • Transforming Growth Factor beta I

Scope note

  • A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.

History note

  • 2007(1992)

In other languages

URI

http://www.yso.fi/onto/mesh/D053773

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