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Nervous System Diseases > Nervous System Malformations > Malformations of Cortical Development > Malformations of Cortical Development, Group II > Lissencephaly
... > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Congenital Abnormalities > Nervous System Malformations > Malformations of Cortical Development > Malformations of Cortical Development, Group II > Lissencephaly

Preferred term

Lissencephaly  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Lissencephalia

Note

  • note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available

Scope note

  • A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.

History note

  • 2008

In other languages

URI

http://www.yso.fi/onto/mesh/D054082

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