Concept information
Preferred term
Perforin
Type
-
Topical Descriptor
Broader concept
Entry terms
- Cytolysin
- Lymphocyte Pore Forming Protein
- Lymphocyte Pore-Forming Protein
- Perforin 1
- Pore-Forming Protein, Lymphocyte
Scope note
- A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
History note
- 2008
In other languages
-
Finnish
-
Swedish
-
Cytolysin
URI
http://www.yso.fi/onto/mesh/D054353
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