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Biological Factors > Intercellular Signaling Peptides and Proteins > Agouti Signaling Protein
Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Agouti Signaling Protein
Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Agouti Signaling Protein

Preferred term

Agouti Signaling Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Agouti Protein
  • Agouti Switch Protein
  • ASIP Protein

Scope note

  • A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.

History note

  • 2008 (1993)

In other languages

URI

http://www.yso.fi/onto/mesh/D054366

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