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Concept information

Preferred term

rho-Associated Kinases  

Type

  • Topical Descriptor

Entry terms

  • Coiled-Coil Kinase, rho-Associated
  • Protein Kinases, ROCK
  • rho Associated Coiled Coil Kinase
  • rho-Associated Coiled-Coil Kinase
  • rho Associated Kinase
  • rho-Associated Kinase
  • rho Kinase
  • rho-Kinase
  • ROCK Protein Kinases
  • ROK Kinase

Scope note

  • A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

History note

  • 2008

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URI

http://www.yso.fi/onto/mesh/D054460

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