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... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Tyrosine Phosphatases > Protein Tyrosine Phosphatases, Non-Receptor > Protein Tyrosine Phosphatase, Non-Receptor Type 22
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Tyrosine Phosphatases > Protein Tyrosine Phosphatases, Non-Receptor > Protein Tyrosine Phosphatase, Non-Receptor Type 22
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Monoester Hydrolases > Protein Tyrosine Phosphatases > Protein Tyrosine Phosphatases, Non-Receptor > Protein Tyrosine Phosphatase, Non-Receptor Type 22

Preferred term

Protein Tyrosine Phosphatase, Non-Receptor Type 22  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Lymphoid Phosphatase
  • Protein Tyrosine Phosphatase Lyp
  • Protein-Tyrosine Phosphatase Lyp
  • PTPase Lyp
  • PTPN 22 Protein
  • PTPN-22 Protein
  • Tyrosine Protein Phosphatase, Non Receptor Type 22
  • Tyrosine Protein Phosphatase, Non-Receptor Type 22

Scope note

  • A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.

History note

  • 2008(1999)

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URI

http://www.yso.fi/onto/mesh/D054596

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