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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > 3',5'-Cyclic-AMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > 3',5'-Cyclic-AMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Diester Hydrolases > 3',5'-Cyclic-AMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > 3',5'-Cyclic-GMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > 3',5'-Cyclic-GMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Diester Hydrolases > 3',5'-Cyclic-GMP Phosphodiesterases > Cyclic Nucleotide Phosphodiesterases, Type 2

Preferred term

Cyclic Nucleotide Phosphodiesterases, Type 2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Cyclic GMP Stimulated Phosphodiesterase
  • Cyclic GMP-Stimulated Phosphodiesterase
  • Cyclic Nucleotide Phosphodiesterase PDE2 Family
  • PDE2 Phosphodiesterase
  • PDE2 Phosphodiesterases
  • Phosphodiesterase, Cyclic GMP-Stimulated

Scope note

  • A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

History note

  • 2008(2000)

In other languages

URI

http://www.yso.fi/onto/mesh/D054678

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