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Musculoskeletal Diseases > Musculoskeletal Abnormalities > Campomelic Dysplasia
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Congenital Abnormalities > Musculoskeletal Abnormalities > Campomelic Dysplasia

Preferred term

Campomelic Dysplasia  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Campomelic Dwarfism
  • Campomelic Dwarfisms
  • Campomelic Syndrome
  • Campomelic Syndromes
  • Camptomelic Dysplasia
  • Camptomelic Dysplasias
  • Cmpd1 Sra1
  • Cmpd1 Sra1s
  • Dwarfism, Campomelic
  • Dwarfisms, Campomelic
  • Dysplasia, Camptomelic
  • Dysplasias, Camptomelic
  • Sra1, Cmpd1
  • Sra1s, Cmpd1
  • Syndrome, Campomelic
  • Syndromes, Campomelic

Scope note

  • A congenital disorder of CHONDROGENESIS and OSTEOGENESIS characterized by hypoplasia of endochondral bones. In most cases there is a curvature of the long bones especially the TIBIA with dimpling of the skin over the bowed areas, malformation of the pelvis and spine, 11 pairs of ribs, hypoplastic scapulae, club feet, micrognathia, CLEFT PALATE, tracheobronchomalacia, and in some patients male-to-female sex reversal (SEX REVERSAL, GONADAL). Most patients die in the neonatal period of respiratory distress. Campomelic dysplasia is associated with haploinsufficiency of the SOX9 TRANSCRIPTION FACTOR gene.

History note

  • 2009

In other languages

URI

http://www.yso.fi/onto/mesh/D055036

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