Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Insulin Receptor Substrate Proteins

Preferred term

Insulin Receptor Substrate Proteins  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • IRS Signaling Adaptor Proteins

Scope note

  • A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

History note

  • 2009(1992)

In other languages

URI

http://www.yso.fi/onto/mesh/D055504

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/08, last modified 5/24/17