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Cell Physiological Phenomena > Endoplasmic Reticulum Stress > Unfolded Protein Response
... > Metabolism > Peptide Biosynthesis > Protein Biosynthesis > Protein Modification, Translational > Protein Processing, Post-Translational > Unfolded Protein Response
... > Chemical Phenomena > Biochemical Phenomena > Peptide Biosynthesis > Protein Biosynthesis > Protein Modification, Translational > Protein Processing, Post-Translational > Unfolded Protein Response
... > Genetic Phenomena > Gene Expression > Protein Biosynthesis > Protein Modification, Translational > Protein Processing, Post-Translational > Unfolded Protein Response
Genetic Phenomena > Gene Expression Regulation > Protein Modification, Translational > Protein Processing, Post-Translational > Unfolded Protein Response

Preferred term

Unfolded Protein Response  

Type

  • Topical Descriptor

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Scope note

  • A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

History note

  • 2010

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URI

http://www.yso.fi/onto/mesh/D056811

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