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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Mediator Complex
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Mediator Complex
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Mediator Complex
Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Mediator Complex
Macromolecular Substances > Multiprotein Complexes > Mediator Complex

Preferred term

Mediator Complex  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Mediator Transcription Complex

Scope note

  • A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

History note

  • 2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009

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URI

http://www.yso.fi/onto/mesh/D056892

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