Concept information
Amino Acids, Peptides, and Proteins
Proteins
Receptors, Cytoplasmic and Nuclear
Orphan Nuclear Receptors
Preferred term
Nuclear Receptor Subfamily 1, Group D, Member 1
Type
-
Topical Descriptor
Entry terms
- NR1D1, Nuclear Receptor
- Nuclear Receptor NR1D1
- Nuclear Receptors, Rev-erb-alpha
- Receptor NR1D1, Nuclear
- Rev erb alpha Nuclear Receptors
- Rev-erb-alpha Nuclear Receptors
- V erbA Related Protein EAR 1
- V-erbA-Related Protein EAR-1
Scope note
- A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
History note
- 2010
In other languages
URI
http://www.yso.fi/onto/mesh/D056953
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}