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Concept information

Preferred term

Nuclear Receptor Subfamily 1, Group D, Member 1  

Type

  • Topical Descriptor

Entry terms

  • NR1D1, Nuclear Receptor
  • Nuclear Receptor NR1D1
  • Nuclear Receptors, Rev-erb-alpha
  • Receptor NR1D1, Nuclear
  • Rev erb alpha Nuclear Receptors
  • Rev-erb-alpha Nuclear Receptors
  • V erbA Related Protein EAR 1
  • V-erbA-Related Protein EAR-1

Scope note

  • A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.

History note

  • 2010

URI

http://www.yso.fi/onto/mesh/D056953

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