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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Sterol 14-Demethylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Sterol 14-Demethylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Sterol 14-Demethylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 51 > Sterol 14-Demethylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 51 > Sterol 14-Demethylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 51 > Sterol 14-Demethylase

Preferred term

Sterol 14-Demethylase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 14 alpha-Demethylase, Eburicol
  • 14alpha-Demethylase, Eburicol
  • 14 alpha-Demethylase, Lanosterol
  • 14alpha-Demethylase, Obtusifoliol
  • 14-alpha-Demethylase, Sterol
  • 14-Demethylases, Sterol
  • CYP51 Cytochrome P 450
  • CYP51 Cytochrome P-450
  • CYP51, Cytochrome P-450
  • Cytochrome P 450 CYP51
  • Cytochrome P-450 CYP51
  • Cytochrome P-450, CYP51
  • Eburicol 14 alpha Demethylase
  • Eburicol 14 alpha-Demethylase
  • Eburicol 14alpha Demethylase
  • Eburicol 14alpha-Demethylase
  • Lanosterol 14 alpha Demethylase
  • Lanosterol 14 alpha-Demethylase
  • Obtusifoliol 14alpha Demethylase
  • Obtusifoliol 14alpha-Demethylase
  • P-450 CYP51, Cytochrome
  • P-450, CYP51 Cytochrome
  • Sterol 14 alpha Demethylase
  • Sterol 14-alpha-Demethylase
  • Sterol 14 Demethylases
  • Sterol 14-Demethylases

Scope note

  • An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

History note

  • 2011

In other languages

URI

http://www.yso.fi/onto/mesh/D058886

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