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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases > 3-Hydroxyacyl CoA Dehydrogenases > Peroxisomal Multifunctional Protein-2
Enzymes and Coenzymes > Enzymes > Multifunctional Enzymes > Peroxisomal Multifunctional Protein-2
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > Hydroxysteroid Dehydrogenases > 17-Hydroxysteroid Dehydrogenases > Peroxisomal Multifunctional Protein-2
... > Enzymes and Coenzymes > Enzymes > Lyases > Carbon-Oxygen Lyases > Hydro-Lyases > Enoyl-CoA Hydratase 2 > Peroxisomal Multifunctional Protein-2

Preferred term

Peroxisomal Multifunctional Protein-2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 17 beta Hydroxysteroid Dehydrogenase 4
  • 17-beta-Hydroxysteroid Dehydrogenase 4
  • 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
  • 4, 17-beta-Hydroxysteroid Dehydrogenase
  • Dehydrogenase 4, 17-beta-Hydroxysteroid
  • Peroxisomal Multifunctional Enzyme Type 2

Scope note

  • A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

History note

  • 2014

In other languages

URI

http://www.yso.fi/onto/mesh/D064029

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