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Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Anaphase-Promoting Complex-Cyclosome
... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Anaphase-Promoting Complex-Cyclosome

Preferred term

Anaphase-Promoting Complex-Cyclosome  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Anaphase Promoting Complex

Scope note

  • An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

History note

  • 2014

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URI

http://www.yso.fi/onto/mesh/D064173

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