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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Cysteine Endopeptidases > Separase
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Cysteine Proteases > Cysteine Endopeptidases > Separase
Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Separase

Preferred term

Separase  

Type

  • Topical Descriptor

Broader concept

Scope note

  • Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.

History note

  • 2014

In other languages

URI

http://www.yso.fi/onto/mesh/D064247

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