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Concept information

Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Securin

Preferred term

Securin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Pituitary Tumor-Transforming Gene Protein
  • Pituitary Tumor Transforming Proteins
  • Pituitary Tumor-Transforming Proteins
  • PTTG Protein

Scope note

  • Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.

History note

  • 2014

In other languages

URI

http://www.yso.fi/onto/mesh/D064249

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