Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Biological Factors > Intercellular Signaling Peptides and Proteins > EGF Family of Proteins > Heparin-binding EGF-like Growth Factor
Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > EGF Family of Proteins > Heparin-binding EGF-like Growth Factor
Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > EGF Family of Proteins > Heparin-binding EGF-like Growth Factor

Preferred term

Heparin-binding EGF-like Growth Factor  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • HB EGF
  • HB-EGF
  • Heparin-binding EGF-like Growth-Factor

Scope note

  • An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.

History note

  • 2015

In other languages

URI

http://www.yso.fi/onto/mesh/D066257

Download this concept:

RDF/XML TURTLE JSON-LD Created 6/26/14, last modified 6/24/14